Oligodendrocytes (OLs), the myelin-forming cells in the central nervous system, may be a possible target for Pb toxicity. The present study describes the effect of Pb on the maturation of rat OL progenitor (OP) cells and the developmental expression of myelin-specific galactolipids.

(1996). Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. (1999). Myelination in the absence of galactolipids and proteolipid proteins. (1994). Myelination in the absence of myelin-associated glycoprotein. (1993). Novel oligodendrocyte transmembrane signaling systems.

Journal of Neurochemistry, 1985. Steven Pfeiffer. Download PDF. Download Full PDF Package. This paper. A short summary of this paper.

Galactolipids in myelination

Myelin-Associated Galactolipids in Primary Cultures from Dissociated Fetal Rat Brain: Biosynthesis, Accumulation, and Cell Surface Expression Martínez M. The developmental lipid profiles in the human cerebrum, cerebellum and brain stem are presented, with special reference to galactolipids as myelin markers to trace myelination in the three main parts of the human CNS. A group of undernourished children were also studied to test the vulnerability of myelinogenesis in the different 1999-07-01 · The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near normal compaction. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near normal compaction. Here, we have generated To investigate further factors involved in regulating myelino‐genesis in these mice, we have focused on the synthesis of cerebrosides and sulfatides, galactolipids enriched in myelin. Brain slices from 14‐, 17‐, and 21‐day‐old D2, B6, and F., mice were incubated with [ 3 H]galactose and [ 35 S]sulfate. Approximately 70% of the dry weight of myelin is lipid, with the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide encompassing about one-third of the lipid mass (reviewed by Norton and Cammer, 1984).

We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain.

The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C. de Jonge, Don C. Lamb, Dick Hoekstra, Nicoletta Kahya *, Wia Baron

Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near normal compaction. The galactolipids galactocerebroside and sulfatide, which require the enzyme UDP-galactose:ceramide galactosyltransferase (CGT) for their synthesis, are among the most prevalent molecules in the myelin sheath.

The role of gangliosides in myelination is mainly associated with their ability to establish and modulate glia axon connections and MAG‐ganglioside downstream signalling (Schmitt et al., 2015). On the contrary of gangliosides, galactolipids, that is GalCer and sulphatides with long fatty acid chains (24:0 and 24:1), are abundant components of the myelin sheath.

(1994). Myelination in the absence of myelin-associated glycoprotein. (1993).

The myelin sheath contains an unusual lipid composition in that the glycolipid galactosylceramide (GalC) and its sulfated form sulfatide constitute a large proportion of the total lipid mass. Approximately 70% of the dry weight of myelin is lipid, with the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide encompassing about one-third of the lipid mass (reviewed by Norton and Cammer, 1984). Myelination in the absence of galactolipids and proteolipid proteins. Coetzee T., Suzuki K., Nave K.A., Popko B. The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein … Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids. We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain. To develop better treatment for these diseases, we must understand the mechanisms involved in myelination. Myelin is a specialized structure with distinct lipid and protein constituents.
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Myelination in the absence of myelin-associated glycoprotein. (1993).

Myelin-Associated Galactolipids in Primary Cultures from Dissociated Fetal Rat Brain: Biosynthesis, Accumulation, and Cell Surface Expression. Journal of Neurochemistry, 1985. Steven Pfeiffer. Download PDF. Download Full PDF Package. This paper. A short summary of this paper.

PY - 2014. Y1 - 2014.

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are Dictated by Distinct Galactolipids and the Extracellular Matrix Hande Ozgen1, Waldemar Schrimpf2, Jelle Hendrix2, Jenny C. de Jonge1, Don C. Lamb2, Dick Hoekstra1, Nicoletta Kahya1 and Wia Baron1 1 Department of Cell Biology, University of Groningen, University Medical Center Groningen, Anto-nius Deusinglaan 1, 9713 AV Groningen, the

Extracellular Matrix. Hande Ozgen1, Waldemar Schrimpf2, Jelle 2-hydroxygalactolipids account for as much as 60% of the myelin sheath, galactolipids in peripheral nervous system myelin” Journal of Lipid Research, vol. This dense network of hydrogen bonds is believed to contribute to the high transition temperature and the compact alignment of the galactolipids.

Förlusten av myelin avbryter normal överföring av nervimpulser. accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE.

Jan 15, 2020 During myelination levels of the major SPT subunits increased and and myelin galactolipids stabilize developing axo-glial interactions. Aug 29, 1970 The finding3,4 of a myelin deficient mouse mutant whose galactolipids and sphingomyelin lack long chain fatty acids led us to investigate Jan 2, 2011 FA2H and other enzymes are responsible for the increase in 2-OH very-long- chain (>C20) fatty acid contents in galactolipids during myelination. Jan 23, 2008 The concentrations of phospholipids and galactolipids and their fatty acid compositions were determined in purified myelin from apparently Oct 1, 2009 Subsequent reactions produce ceramide, the precursor for galactolipids, gangliosides, and sphingomyelin (FIGURE 1). The enzyme Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these Myelin is enriched in galactolipids and cholesterol and contains myelin-specific proteins, the major ones of which are myelin basic protein (MBP) and proteolipid Dynamics of Myelin Proteins PLP and MBP are Dictated by Distinct Galactolipids and the.

In this report, we show that FA2H also plays a major role in the formation of 2-hydroxy Astrocytes, Implications for Myelination and Remyelination Veronica T. Cheli1, J. Correale2, Pablo M. Paez1 and Juana M. Pasquini3 Abstract Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Se hela listan på frontiersin.org Oligodendrocytes (OLs), the myelin-forming cells in the central nervous system, may be a possible target for Pb toxicity. The present study describes the effect of Pb on the maturation of rat OL progenitor (OP) cells and the developmental expression of myelin-specific galactolipids. "Galactolipids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Abstract Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty glycosphingolipids; myelination; mouse mutant; maturation. ABSTRACT which are incapable of synthesizing the myelin galactolipids, here we show that there. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J. Neurosci.